Science. 1994 Dec 16;266(5192):1865-9.

Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma.

Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, Moore PS.

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Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.

Abstract

Representational difference analysis was used to isolate unique sequences present in more than 90 percent of Kaposi's sarcoma (KS) tissues obtained from patients with acquired immunodeficiency syndrome (AIDS). These sequences were not present in tissue DNA from non-AIDS patients, but were present in 15 percent of non-KS tissue DNA samples from AIDS patients. The sequences are homologous to, but distinct from, capsid and tegument protein genes of the Gammaherpesvirinae, herpesvirus saimiri and Epstein-Barr virus. These KS-associated herpesvirus-like (KSHV) sequences appear to define a new human herpesvirus.

Comment in

Is a new virus the cause of KS? [Science. 1994]
Is a new virus the cause of KS?Cohen J. Science. 1994 Dec 16; 266(5192):1803-4.
AIDS-associated Kaposi's sarcoma. [Science. 1995]
AIDS-associated Kaposi's sarcoma.Jones JL, Hanson DL, Chu SY, Ward JW, Jaffe HW. Science. 1995 Feb 24; 267(5201):1078-9.
Herpes-like sequences in HIV-infected and uninfected Kaposi's sarcoma patients. [Science. 1995]
Herpes-like sequences in HIV-infected and uninfected Kaposi's sarcoma patients.Ambroziak JA, Blackbourn DJ, Herndier BG, Glogau RG, Gullett JH, McDonald AR, Lennette ET, Levy JA. Science. 1995 Apr 28; 268(5210):582-3.

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Science. 1994 Dec 16 ;266(5192):1865-9.

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