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    Nature. 1994 Dec 22-29;372(6508):746-54.

    Crystal structure of the tyrosine kinase domain of the human insulin receptor.

    Hubbard SR, Wei L, Ellis L, Hendrickson WA.

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    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032.

    Abstract

    The X-ray crystal structure of the tyrosine kinase domain of the human insulin receptor has been determined by multiwavelength anomalous diffraction phasing and refined to 2.1 A resolution. The structure reveals the determinants of substrate preference for tyrosine rather than serine or threonine and a novel autoinhibition mechanism whereby one of the tyrosines that is autophosphorylated in response to insulin, Tyr 1,162, is bound in the active site.

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    PMID:
    7997262
    [PubMed - indexed for MEDLINE]

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