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Nature. 1994 Dec 22-29;372(6508):746-54.

Crystal structure of the tyrosine kinase domain of the human insulin receptor.

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  • 1Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032.

Abstract

The X-ray crystal structure of the tyrosine kinase domain of the human insulin receptor has been determined by multiwavelength anomalous diffraction phasing and refined to 2.1 A resolution. The structure reveals the determinants of substrate preference for tyrosine rather than serine or threonine and a novel autoinhibition mechanism whereby one of the tyrosines that is autophosphorylated in response to insulin, Tyr 1,162, is bound in the active site.

PMID:
7997262
[PubMed - indexed for MEDLINE]
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