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Postgrad Med. 1994 Dec;96(8):119-25.

Obsessive-compulsive disorder. How to free patients from intrusive thoughts and rituals.

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  • 1Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine.


The antidepressants clomipramine hydrochloride (Anafranil), fluoxetine hydrochloride (Prozac), and sertraline hydrochloride (Zoloft) are the main choices for pharmacologic treatment of obsessive-compulsive disorder. Often, drug doses for obsessive-compulsive disorder are higher than for depression, and improvement occurs more slowly and is often only partial. Behavior therapy involving exposure to feared objects or situations and prevention of ritualistic behavior complements pharmacologic treatment. Referral to a behavioral therapist may be necessary to achieve recovery.

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