Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nature. 1994 Dec 15;372(6507):631-4.

Protein superfamilies and domain superfolds.

Author information

  • 1Biochemistry and Molecular Biology Department, University College London, UK.

Abstract

As the protein sequence and structure databases expand rapidly a better understanding of the relationships between proteins is required. A classification is considered that extends the sequence-based superfamilies to include proteins with similar function and three-dimensional structures but no sequence similarity. So far there are only nine protein folds known to recur in proteins having neither sequence nor functional similarity. These folds dominate the structure database, representing more than 30 per cent of all determined structures. This observation has implications for protein-fold recognition.

PMID:
7990952
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk