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Eur J Pharmacol. 1994 Aug 1;260(2-3):233-5.

Effect of valepotriates on the behavior of rats in the elevated plus-maze during diazepam withdrawal.

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  • 1Departamento de Psicobiologia, Escola Paulista de Medicina, São Paulo, Brazil.


The effect of a mixture of valepotriates on the elevated plus-maze performance of diazepam withdrawn rats was evaluated. The rats were chronically (28 days) treated with diazepam (doses increased up to 5.0 mg/kg) and then treated with control solution for 3 days to induce a withdrawal syndrome. Chronically vehicle-treated rats were used as control. The abstinent animals treated with vehicle showed a significant decrease in the percentage of time spent in the open arms when compared with the control animals. Diazepam and valerian 12.0 mg/kg reversed this anxiogenic effect. Valerian 6.0 mg/kg did not show any difference in relation to the others group.

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