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    Trends Genet. 1994 Oct;10(10):376-80.

    How flies make one equal two: dosage compensation in Drosophila.

    Gorman M, Baker BS.

    Source

    Department of Biological Sciences, Stanford University, CA 94305.

    Abstract

    Dosage compensation is the process by which the expression of X-linked genes is equalized in males and females. In Drosophila, dosage compensation occurs by coordinately upregulating the transcription rates of all the genes on the single X chromosome in males. This hypertranscription requires the functioning of four autosomal male-specific lethal (msl) genes and is under the control of the Sxl gene. Recent genetic and molecular studies have suggested that the msl proteins may associate with one another in a sex-specific heteromeric complex on the male X chromosome, where they may function to alter its chromatin structure.

    PMID:
    7985243
    [PubMed - indexed for MEDLINE]

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