Display Settings:

Format

Send to:

Choose Destination
Nihon Rinsho. 1994 Oct;52(10):2673-85.

[The role of phosphorylation cascade in insulin action].

[Article in Japanese]

Author information

  • 1Internal Medicine III, Faculty of Medicine, University of Tokyo.

Abstract

Insulin induces a wide variety of growth and metabolic response in many cell types. Insulin initiates its biological effects by activation of tyrosine kinase in the beta-subunit and phosphorylates several proteins, such as insulin receptor substrate-1 (IRS-1), Shc. thereby activating phosphatidyl inositol 3-kinase activity, and ras activity. MAP kinase cascade activated by ras, 70kDaS6 kinase lying downstream of PI3-kinase, and the regulation of glycogen synthase have been discussed.

PMID:
7983797
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk