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Nihon Rinsho. 1994 Oct;52(10):2673-85.

[The role of phosphorylation cascade in insulin action].

[Article in Japanese]

Author information

  • 1Internal Medicine III, Faculty of Medicine, University of Tokyo.


Insulin induces a wide variety of growth and metabolic response in many cell types. Insulin initiates its biological effects by activation of tyrosine kinase in the beta-subunit and phosphorylates several proteins, such as insulin receptor substrate-1 (IRS-1), Shc. thereby activating phosphatidyl inositol 3-kinase activity, and ras activity. MAP kinase cascade activated by ras, 70kDaS6 kinase lying downstream of PI3-kinase, and the regulation of glycogen synthase have been discussed.

[PubMed - indexed for MEDLINE]
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