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Genetics. 1994 Aug;137(4):1089-100.

A primary linkage map of the porcine genome reveals a low rate of genetic recombination.

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  • 1Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala.

Abstract

A comprehensive genetic linkage map of the porcine genome has been developed by typing 128 genetic markers in a cross between the European Wild Boar and a domestic breed (Large White). The marker set includes 68 polymerase chain reaction-formatted microsatellites, 60 anchored reference markers informative for comparative mapping and 47 markers which have been physically assigned by in situ hybridization. Novel multipoint assignments are provided for 54 of the markers. The map covers about 1800 cM, and the average spacing between markers is 11 cM. We used the map data to estimate the genome size in pigs, thereby addressing the total recombination distance in a third mammalian species. A sex-average genome length of 1873 +/- 139 cM was obtained by comparing the recombinational and physical distances in defined regions of the genome. This is strikingly different from the length of the human genome (3800-4000 cM) and is more similar to the mouse estimate (1600 cM). The recombination rate in females was significantly higher than in males.

PMID:
7982563
[PubMed - indexed for MEDLINE]
PMCID:
PMC1206056
Free PMC Article
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