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FEBS Lett. 1994 Nov 28;355(2):114-6.

Inhibition of the respiratory burst in mouse macrophages by ultra-low doses of an opioid peptide is consistent with a possible adaptation mechanism.

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  • 1Belozersky Institute of Physico-Chemical Biology, Moscow State University, Russian Federation.


The respiratory burst induced by phorbol myristate acetate in mouse macrophages was inhibited by ultra-low doses (10(-15)-10(-13) M) of an opioid peptide [D-Ala2]methionine enkephalinamide. The effect disappeared at concentrations above and below this range. The inhibition approached 50% and was statistically significant (P < 0.001). Increasing the time of the opioid incubation with cells brought about a shift in the maximal effect to lower concentrations of the opioid (from 10(-13) to 5 x 10(-15) M) and led to a decrease in the value of the effect, fully in accord with the previously proposed adaptation mechanism of the action of ultra-low doses.

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