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Vaccine. 1994 Jul;12(9):857-63.

Antigenicity and immunogenicity of experimental equine influenza ISCOM vaccines.

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  • 1Animal Health Trust, Lanwades Park, Kennett, Suffolk, UK.


A comparison of the antigenicity and immunogenicity of ISCOM vaccines prepared from equine influenza viruses H3N8 and H7N7 was made with inactivated whole-virus vaccines containing equivalent amounts of virus haemagglutinin. ISCOMs stimulated superior antibody responses in terms of both amount and duration. As with conventional whole-virus vaccines, the levels of antibody to virus haemagglutinin induced by ISCOMs correlated with protection.

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