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Trends Genet. 1994 Sep;10(9):315-20.

The LIM domain: a new structural motif found in zinc-finger-like proteins.

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  • 1Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.


An important new family of proteins has recently been described that carries a novel cysteine-rich zinc-binding domain called the LIM domain. This protein family is present in mammals, amphibians, flies, worms and plants and its main function is in developmental regulation. Although a role in protein-protein interaction seems likely, intriguing similarities to GATA zinc fingers imply that the LIM domain may also be involved in binding to specific nucleic acids.

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