Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):11158-62.

Centrally active modulators of glutamate receptors facilitate the induction of long-term potentiation in vivo.

Stäubli U, Perez Y, Xu FB, Rogers G, Ingvar M, Stone-Elander S, Lynch G.

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New York University, Center for Neural Science, NY 10003.

Abstract

An experimental drug, 1-(1,3-benzodioxol-5-ylcarbonyl)piperidine, that facilitates glutamatergic transmission in brain after systemic administration was tested for its effects on the induction of long-term potentiation in the hippocampus of rats. Intraperitoneal injections of the drug markedly increased the degree and duration of long-term potentiation; similar results were obtained with an analogue of 1-(1,3-benzodioxol-5-ylcarbonyl)piperidine that was also found to improve retention of memory in a radial maze task and in an odor-matching problem. These results define tools for enhancing long-term potentiation in vivo and confirm an important prediction from the hypothesis that long-term potentiation is a substrate of memory.

PMID:: 7972026; [PubMed - indexed for MEDLINE]
PMCID: PMC45186

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Centrally active modulators of glutamate receptors facilitate the induction of long-term potentiation in vivo.

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