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Neurosci Lett. 1994 Jun 6;174(1):9-13.

Role of arachidonic acid in the facilitation of glutamate release from rat cerebrocortical synaptosomes independent of metabotropic glutamate receptor responses.

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  • 1Departamento de Bioquímica, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain.


The role of arachidonic acid in the facilitation of glutamate release by the metabotropic glutamate receptor, mGluR, agonist (1S,3R)-1-amino-cyclo-pentane-1,3-dicarboxylate ((1S,3R)-ACP), was investigated in cerebrocortical nerve terminals from adult rats. mGluR activation with the agonist (1S,3R)-ACPD involved a transient increase in the intrasynaptosomal concentration of diacylglycerol that was not altered by the presence of arachidonic acid either in polarized synaptosomes, or in synaptosomes depolarized with 4-aminopyridine. These results suggest that the locus of the arachidonic acid action in the facilitation of glutamate release is downstream of the metabotropic glutamate receptor in the signal transduction pathway.

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