Neurosci Lett. 1994 Jun 6;174(1):113-6.

Glucocorticoid treatment increases the ability of CRH to induce seizures.

Rosen JB, Pishevar SK, Weiss SR, Smith MA, Kling MA, Gold PW, Schulkin J.

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Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892.

Abstract

We examined whether glucocorticoids could enhance the ability of corticotropin-releasing hormone (CRH) to induce seizures. Rats were treated with systemic glucocorticoids (dexamethasone, 100 micrograms) or vehicle for either 3 days (chronic) or 2 h (acute) before intracerebroventricular CRH (3 or 10 micrograms) or saline injections and then monitored for 8 h following each injection. Our results suggest that chronic, but not acute, glucocorticoid pretreatment increases the likelihood of CRH-induced seizures.

PMID:: 7970144; [PubMed - indexed for MEDLINE]

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