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J Clin Psychopharmacol. 1994 Aug;14(4):241-6.

A multicenter double-blind trial of paroxetine versus amitriptyline in depressed inpatients.

Author information

  • 1Department of Psychiatry, Innsbruck University Hospital, Austria.

Abstract

The phenylpiperidine derivative paroxetine is a selective serotonin reuptake inhibitor. In a double-blind 6-week trial, paroxetine was compared with amitriptyline in hospitalized patients suffering from major depression (DSM-III). One hundred fifty-three patients were enrolled in the study in seven centers in Austria and Germany. Results showed similar efficacy of both drugs after 6 weeks. The differences between groups in Montgomery-Asberg Depression Rating Scale and Clinical Global Impression ratings did not reach statistical significance at any time. Side effects were distributed similarly but with a significantly higher incidence of anticholinergic effects in patients treated with amitriptyline (p < or = 0.001), whereas agitation and insomnia were registered more often in the paroxetine group. This study supports the antidepressive efficacy of paroxetine in a sample of severely depressed inpatients.

PMID:
7962679
[PubMed - indexed for MEDLINE]
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