Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below

Treatment of elective mutism with fluoxetine: a double-blind, placebo-controlled study.

Author information

  • 1Department of Psychiatry, New England Medical Center, Boston, MA 02111.

Abstract

OBJECTIVE:

To evaluate the efficacy of treatment with fluoxetine in reducing symptoms associated with elective mutism.

METHOD:

Sixteen subjects with elective mutism were treated with placebo (single-blind) for 2 weeks. Fifteen placebo nonresponders were then randomly assigned to double-blind treatment with fluoxetine at a dose of 0.6 mg/kg/day (N = 6) or continued placebo (N = 9) for an additional 12 weeks. Outcome ratings were completed by the treating psychiatrist, parents, and teachers.

RESULTS:

Significant improvements over time on ratings of elective mutism, anxiety, and social anxiety, rated by clinician, parents, and teachers, were demonstrated in both fluoxetine- and placebo-treated subjects. Subjects treated with fluoxetine were significantly more improved than placebo-treated subjects on parent's ratings of mutism change and global change. Clinician and teacher ratings did not reveal significant differences between treatment groups. Although improved, most subjects in both treatment groups remained very symptomatic at the end of the study period. Side effects were minimal.

CONCLUSION:

Fluoxetine may be beneficial and safe in the treatment of children with elective mutism. Longer periods of treatment may yield more substantial therapeutic benefits. Further study is indicated.

Comment in

  • Fluoxetine for (s)elective mutism. [J Am Acad Child Adolesc Psychiatry. 1995]
PMID:
7961338
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk