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FEBS Lett. 1994 Oct 31;354(1):50-2.

Degradation of the yeast MAT alpha 2 transcriptional regulator is mediated by the proteasome.

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  • 1Institut für Biochemie, Universität Stuttgart, Germany.

Erratum in

  • FEBS Lett 1995 Jan 16;358(1):104.


Rapid degradation of specific regulatory proteins plays a role in a wide range of cellular phenomena, including cell cycle progression and the regulation of cell growth and differentiation. A major mechanism of selective protein turnover in vivo involves a large multi-subunit protease known as the proteasome or multi-catalytic proteinase. At the same time, the degradation of many cellular proteins requires their covalent ligation to the polypeptide ubiquitin. Here we show that the yeast S. cerevisiae MAT alpha 2 repressor, which is known to be ubiquitinylated in vivo, requires the proteasome for its rapid intracellular proteolysis.

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