Divalproex sodium was given to a series of agitated individuals with a variety of psychiatric illnesses. Objective measures of agitation were then used to assess the effect of the divalproex sodium on such behavior. Demographic, diagnostic, medical, and physiological data were compiled on the subjects and the variation in the amount of time spent in an agitated state was evaluated in an attempt to account for the variation. We found that divalproex sodium reduced agitation in a variety of psychiatric conditions. It seems to be especially effective in the treatment of the agitated patient with bipolar illness or borderline personality disorder.