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Urology. 1994 Oct;44(4):614-6.

Cimetidine in the treatment of interstitial cystitis.

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  • 1Department of Urology, Queen's University, Kingston, Ontario, Canada.

Abstract

OBJECTIVES:

To assess the effect of the H2-antagonist cimetidine in the treatment of patients with interstitial cystitis (IC) refractory to other conservative therapies.

METHODS:

A group of 9 patients previously treated conservatively for IC without success were entered in the study. They were thoroughly investigated and treated with cimetidine at the dose of 300 mg orally twice a day for 1 month.

RESULTS:

Six of the 9 patients (66%) experienced various degrees of symptomatic relief while on the drug. Of these, 4 (44%) have noted a complete and sustained response to the medication.

CONCLUSIONS:

The encouraging results observed in this pilot study together with the simplicity and tolerance of the treatment makes it an alternative when other options have been exhausted. Its use as a first-line monotherapy remains speculative.

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PMID:
7941209
[PubMed - indexed for MEDLINE]
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