Immune response to phi X 174 in man. 5. Primary and secondary antibody production in primary biliary cirrhosis

Gut. 1976 Nov;17(11):844-8. doi: 10.1136/gut.17.11.844.

Abstract

In primary biliary cirrhosis, the primary immune response to the bacteriophage phi X 174 is normal but the secondary response is significantly reduced. The reduction is primarily of IgG antibody, while IgM is proportionately less affected. These changes may be the result of a reduction in helper T lymphocyte function and may contribute to the increase in the ratio of serum concentration of IgM to IgG.

MeSH terms

  • Adult
  • Aged
  • Antibody Formation*
  • Antigens, Viral / administration & dosage
  • Coliphages / immunology*
  • Female
  • Humans
  • Immunoglobulin G / analysis
  • Immunoglobulin M / analysis
  • Immunologic Techniques
  • Liver Cirrhosis, Biliary / immunology*
  • Lymphocyte Activation
  • Middle Aged

Substances

  • Antigens, Viral
  • Immunoglobulin G
  • Immunoglobulin M