J Antimicrob Chemother. 1994 Jun;33(6):1127-35.

Phosphorylative inactivation of rifampicin by Nocardia otitidiscaviarum.

Yazawa K, Mikami Y, Maeda A, Morisaki N, Iwasaki S.

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Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.

Abstract

Rifampicin was inactivated by Nocardia otitidiscaviarum to yield two products designated RIP-3 and RIP-4. The full structures of RIP-3 and RIP-4 were determined to be 21-(O-phosphoryl) rifampicin and 3-formyl-21-(O-phosphoryl) rifamycin SV, respectively, but neither product had any antimicrobial activity.

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Phosphorylative inactivation of rifampicin by Nocardia otitidiscaviarum.
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