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Hum Genet. 1994 Oct;94(4):423-6.

Parental origin of the extra chromosomes in polysomy X.

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  • 1División de Genética, Guadalajara, Jal., Mexico.

Abstract

Five polymorphic index markers were analyzed by polymerase chain reaction (PCR) to ascertain the parental origin of the extra X chromosomes in seven polysomic cases (one 49,XXXXX, three 49,XXXXY, two 48,XXXY, and one 48,XXYY). All four X chromosomes in 49, X polysomies were maternal in origin and the extra X chromosomes in 48 X polysomies were paternal. In each case the multiple X chromosomes were contributed by a single parent. Taken together with previously reported cases, these data support a single mechanism of sequential nondisjunction during either maternal or paternal gametogenesis as the cause of higher order sex chromosome polysomy.

PMID:
7927341
[PubMed - indexed for MEDLINE]
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