Induction of a dominant negative CREB transgene sp...[Cell. 1994]

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1: Cell. 1994 Oct 7;79(1):49-58. Links

Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila.

Yin JC, Wallach JS, Del Vecchio M, Wilder EL, Zhou H, Quinn WG, Tully T.

Cold Spring Harbor Laboratory, New York 11724.

Consolidated memory after olfactory learning in Drosophila consists of two components, a cycloheximide-sensitive, long-term memory (LTM) and a cycloheximide-insensitive, anesthesia-resistant memory (ARM). Using an inducible transgene that expresses a dominant negative member of the fly CREB family, LTM was specifically and completely blocked only after induction, while ARM and learning were unaffected. These results suggest that LTM formation requires de novo gene expression probably mediated by CREB family genes.

PMID: 7923376 [PubMed - indexed for MEDLINE]

CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila. [Cell. 1995]
The role of cAMP response element-binding protein in Drosophila long-term memory. [J Neurosci. 2004]
Genetic dissection of consolidated memory in Drosophila. [Cell. 1994]
A clock gene, period, plays a key role in long-term memory formation in Drosophila. [Proc Natl Acad Sci U S A. 2004]
Exclusive consolidated memory phases in Drosophila. [Science. 2004]
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Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila.

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