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Brain Res. 1994 Jun 6;647(2):340-4.

Neurotrophin-4 selectively promotes survival of striatal neurons in organotypic slice culture.

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  • 1Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110.


The neurotrophins (NGF, BDNF, NT-3, and NT-4) provide trophic support to subpopulations of neurons in the central and peripheral nervous systems. We examined organotypic slices of neonatal mouse striatum maintained in medium supplemented with neurotrophins or with CNTF to determine which of these factors influence the survivability of striatal neurons. Neuron counts at the end of the culture period revealed that NT-4 was the only factor that had a significant effect on neuronal survival, suggesting that NT-4 is a trophic factor for striatal neurons in organotypic slices.

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