Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Matrix Biol. 1994 Apr;14(3):203-8.

Perlecan: a gem of a proteoglycan.

Author information

  • 1Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.

Abstract

Perlecan, the main proteoglycan of basement membranes and pericellular spaces, is one of the largest single-chain polypeptides of vertebrate animals. The five modules of perlecan are collated from protein building blocks evolutionarily related to molecules involved in nutrient metabolism, mitogenesis and adhesion. These structural motifs, when translated into multimeric functional units, could be effectively utilized by diverse tissues during development, remodelling or neoplastic growth. The protein is highly conserved across species and the available data indicate that this modular proteoglycan has evolved from ancient ancestors by gene duplication and exon shuffling. The discovery of a related molecule in the nematode C. elegans, and the development of skeletal muscle abnormalities in this animal when the perlecan-like molecule is truncated, opens new avenues of research.

PMID:
7921536
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk