Nat Genet. 1994 Jun;7(2):169-75.

The origin of the major cystic fibrosis mutation (delta F508) in European populations.

Morral N, Bertranpetit J, Estivill X, Nunes V, Casals T, Giménez J, Reis A, Varon-Mateeva R, Macek M Jr, Kalaydjieva L, et al.

Source

Institut de Recerca Oncològica, Hospital Duran i Reynals, Barcelona, Catalunya, Spain.

Abstract

delta F508 is the most frequent cystic fibrosis (CF) mutation and accounts for approximately 70% of CF chromosomes worldwide. Three highly polymorphic microsatellite markers have been used to study the origin and evolution of delta F508 chromosomes in Europe. Haplotype data demonstrate that delta F508 occurred more than 52,000 years ago, in a population genetically distinct from any present European group, and spread throughout Europe in chronologically distinct expansions, which are responsible for the different frequencies of delta F508 in Europe.

Comment in

Nat Genet. 1994 Nov;8(3):216-8.

PMID:: 7920636; [PubMed - indexed for MEDLINE]

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Research Support, Non-U.S. Gov't

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Genetic Markers

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Cystic fibrosis in the Basque country: high frequency of mutation delta F508 in patients of Basque origin. [Am J Hum Genet. 1992]
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