Abstract
The Et2O-soluble fraction of the MeOH extract of the leaves of Aucuba japonica Thunb. showed an anti-inflammatory effect when topically applied to rats. E-Phytol, phytone, bis(2-ethylhexyl)phthalate and friedelin were isolated as active anti-inflammatory components inhibiting carrageenin-induced paw edema. The most effective, E-phytol, inhibited histamine-induced paw edema more potently than the compound 48/80-induced edema, suggesting that the mechanism of action is due to inhibition of the H1 receptor.
MeSH terms
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Administration, Topical
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Animals
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / pharmacology*
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Carrageenan
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Cyclooxygenase Inhibitors / pharmacology
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / pharmacology*
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Edema / chemically induced
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Edema / prevention & control
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Histamine H1 Antagonists / pharmacology
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Rats
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p-Methoxy-N-methylphenethylamine / pharmacology
Substances
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Anti-Inflammatory Agents
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Anti-Inflammatory Agents, Non-Steroidal
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Cyclooxygenase Inhibitors
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Drugs, Chinese Herbal
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Histamine H1 Antagonists
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Plant Extracts
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p-Methoxy-N-methylphenethylamine
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Carrageenan