Br J Anaesth. 1994 Aug;73(2):237-8.

Gastric emptying is delayed at 8-12 weeks' gestation.

Levy DM, Williams OA, Magides AD, Reilly CS.

Source

Department of Surgical and Anaesthetic Sciences, University of Sheffield, Royal Hallamshire Hospital.

Abstract

Gastric emptying was studied indirectly by paracetamol absorption in 20 patients at 8-12 weeks' gestation and also in 20 non-pregnant controls. Subjects received paracetamol 1.5 g in a tablet with 50 ml of water and remained semi-recumbent for 2 h while venous blood samples were obtained at 15-min intervals. The maximum concentration of paracetamol was significantly lower and the time to maximum concentration significantly greater in pregnant patients. In addition, the areas under the time-concentration curves at 60 and 120 min were significantly smaller in the pregnant group. These changes are indicative of a delay in gastric emptying at 8-12 weeks' gestation.

PMID:: 7917742; [PubMed - indexed for MEDLINE]

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Acetaminophen

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ACETAMINOPHEN - HSDB

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Related citations in PubMed

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