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Assignment of the human gene for the alpha 1 subunit of the skeletal muscle DHP-sensitive Ca2+ channel (CACNL1A3) to chromosome 1q31-q32.
Department of Anesthesiology, University of Wisconsin, Madison 53705.
A human clone corresponding to the gene encoding the alpha 1 subunit of the skeletal muscle dihydropyridine-sensitive calcium channel (CACNL1A3) has been isolated and partially sequenced. Oligonucleotides based on this sequence were used in a polymerase chain reaction to amplify specifically the human gene in human-rodent somatic cell hybrids, allowing the assignment of CACNL1A3 to chromosome 1. A polymorphic dinucleotide repeat also was identified in the human clone and using PCR was typed on a subset of the CEPH families. Multipoint linkage analysis places the CACNL1A3 gene between D1S52 and D1S70, on chromosome 1q31-q32.
PMID: 7916735 [PubMed - indexed for MEDLINE]
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Cited by 5 PubMed Central articles
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Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication.
Burgess DL, Davis CF, Gefrides LA, Noebels JL.
Genome Res. 1999 Dec; 9(12):1204-13.
[Genome Res. 1999]
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Mutation in DHP receptor alpha 1 subunit (CACLN1A3) gene in a Dutch family with hypokalaemic periodic paralysis.
Boerman RH, Ophoff RA, Links TP, van Eijk R, Sandkuijl LA, Elbaz A, Vale-Santos JE, Wintzen AR, van Deutekom JC, Isles DE.
J Med Genet. 1995 Jan; 32(1):44-7.
[J Med Genet. 1995]
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Mapping of a further malignant hyperthermia susceptibility locus to chromosome 3q13.1.
Sudbrak R, Procaccio V, Klausnitzer M, Curran JL, Monsieurs K, van Broeckhoven C, Ellis R, Heyetens L, Hartung EJ, Kozak-Ribbens G.
Am J Hum Genet. 1995 Mar; 56(3):684-91.
[Am J Hum Genet. 1995]
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