Cell Growth Differ. 1993 Nov;4(11):931-7.

Human CREM gene: evolutionary conservation, chromosomal localization, and inducibility of the transcript.

Masquilier D, Foulkes NS, Mattei MG, Sassone-Corsi P.

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Laboratoire de Génétique Moléculaire des Eucaryotes, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale (INSERM), Faculté de Médecine, Strasbourg, France.

Abstract

The CREM (cyclic AMP-responsive element modulator) gene encodes multiple regulators of the cyclic AMP transcriptional response. CREM expression has been linked with several key physiological aspects of neuroendocrine pathways. We investigated the conservation of CREM during evolution. Here, we show conservation of CREM sequences in the pig, humans, the chicken, the lemur, and Xenopus. We have also determined the chromosomal localization of the CREM and CREB genes both in the mouse and in humans. We cloned the full human CREM complementary DNA sequence and demonstrate that it has a high degree of sequence identity with the mouse gene. Finally, we show the conservation of CREM cyclic AMP transcriptional inducibility in humans and establish that the induced transcripts correspond to the mouse ICER products.

PMID:: 7916662; [PubMed - indexed for MEDLINE]

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