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N Engl J Med. 1994 Jun 9;330(23):1663-70.

The pharmacology and use of H1-receptor-antagonist drugs.

Author information

  • 1Faculty of Medicine, University of Manitoba, Winnipeg, Canada.

Abstract

The second-generation H1-antagonist drugs are supplanting their predecessors in the treatment of allergic rhinoconjunctivitis and chronic urticaria. Their use can be justified mainly on the basis of a more favorable risk-benefit ratio, because they are less toxic to the central nervous system. Future research into H1 antagonists should include additional dose-response studies in patients with allergic disorders, especially children and the elderly; objective studies of adverse effects; studies of topical mucosal application of H1 antagonists; and studies of H1-antagonist enantiomers and active metabolites. With the cloning of the gene encoding the H1 receptor and increased understanding of the precise structural requirements for H1-receptor activity, H1 antagonists with an even more favorable therapeutic index may be developed.

Comment in

  • Histamine H1 antagonists. [N Engl J Med. 1994]
  • Histamine H1 antagonists. [N Engl J Med. 1994]
  • Histamine H1 antagonists. [N Engl J Med. 1994]
  • Histamine H1 antagonists. [N Engl J Med. 1994]
PMID:
7909915
[PubMed - indexed for MEDLINE]
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