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Lancet. 1994 Apr 16;343(8903):955-7.

Disrupted dichotomous intracellular control of human papillomavirus infection in cancer of the cervix.

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  • 1Deutsches Krebsforschungszentrum, Heidelberg, Germany.


The role of specific human papillomaviruses (HPVs) in the aetiology of cancer of the cervix is firmly established. Progression of an HPV-infected cell clone to invasive growth involves consecutive modifications of a set of host cell genes. Some of these modifications suppress viral oncogene functions post-transcriptionally, and others suppress transcription via a signalling pathway stimulated by activated macrophages and possibly by additional cells. I describe a scheme that tries to unify available data by postulating the existence of two intracellular signalling pathways in the control of latent HPV infections.

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