Format

Send to:

Choose Destination
See comment in PubMed Commons below
Lancet. 1994 Apr 16;343(8903):955-7.

Disrupted dichotomous intracellular control of human papillomavirus infection in cancer of the cervix.

Author information

  • 1Deutsches Krebsforschungszentrum, Heidelberg, Germany.

Abstract

The role of specific human papillomaviruses (HPVs) in the aetiology of cancer of the cervix is firmly established. Progression of an HPV-infected cell clone to invasive growth involves consecutive modifications of a set of host cell genes. Some of these modifications suppress viral oncogene functions post-transcriptionally, and others suppress transcription via a signalling pathway stimulated by activated macrophages and possibly by additional cells. I describe a scheme that tries to unify available data by postulating the existence of two intracellular signalling pathways in the control of latent HPV infections.

PMID:
7909014
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk