Format

Send to:

Choose Destination
See comment in PubMed Commons below
FEBS Lett. 1994 Mar 21;341(2-3):256-8.

beta-Cyclodextrin interacts with the Alzheimer amyloid beta-A4 peptide.

Author information

  • 1Departments of Analytical Science, SmithKline Beecham Pharmaceuticals, The Frythe, Welwyn, Herts, UK.

Abstract

Electrospray ionisation mass spectrometry has been used to show that the synthetic 40 amino acid beta-amyloid peptide (beta 1-40) interacts with the cyclic oligosaccharide beta-cyclodextrin. This interaction, presumably with the hydrophobic aromatic moieties on the peptide, has been shown to diminish substantially the neurotoxic effects of beta 1-40 in a cell line.

PMID:
7907994
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk