Translation factors as effectors of cell growth and tumorigenesis

Curr Opin Cell Biol. 1993 Dec;5(6):955-60. doi: 10.1016/0955-0674(93)90076-3.

Abstract

Regulation of translation plays an important role in controlling gene expression. Recent data show that deregulation of translation factor activity leads to drastic changes in cell growth, including transformation and tumorigenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology*
  • Cell Transformation, Neoplastic / genetics*
  • Eukaryotic Cells / cytology
  • Eukaryotic Cells / metabolism
  • Eukaryotic Initiation Factor-4E
  • Gene Expression Regulation / physiology*
  • Models, Biological
  • Peptide Elongation Factor 1
  • Peptide Elongation Factors / genetics
  • Peptide Elongation Factors / physiology*
  • Peptide Initiation Factors / genetics
  • Peptide Initiation Factors / physiology*
  • Phosphorylation
  • Protein Processing, Post-Translational
  • Protein Serine-Threonine Kinases / physiology
  • Proto-Oncogenes
  • eIF-2 Kinase

Substances

  • Eukaryotic Initiation Factor-4E
  • Peptide Elongation Factor 1
  • Peptide Elongation Factors
  • Peptide Initiation Factors
  • Protein Serine-Threonine Kinases
  • eIF-2 Kinase