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Neurosci Lett. 1993 Dec 12;163(2):155-8.

Anti-glutamatergic effects of clozapine.

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  • 1NYS Institute for Basic Research, Staten Island, NY 10314.


Clozapine (Cz) is unique in its efficacy with treatment refractory patients and its freedom from motor side effects. The present work shows that Cz, even after dopamine depletion, suppresses responses evoked via the monosynaptic glutamatergic corticostriatal pathway. In addition, Cz is effective in displacing [3H]MK-801 from striatal homogenates. These data indicate that Cz is a glutamate antagonist. It is unclear, however, if this pharmacological action could explain Cz's lack of motor effects and it's antipsychotic potency.

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