Left ventricular performance and cerebral haemodynamics during xenon anaesthesia. A transoesophageal echocardiography and transcranial Doppler sonography study

Anaesthesia. 1993 Dec;48(12):1045-9. doi: 10.1111/j.1365-2044.1993.tb07522.x.

Abstract

The effects of xenon anaesthesia on myocardial function and cerebral blood flow velocities were investigated with transoesophageal echocardiography and transcranial Doppler sonography. Seventeen ASA 1 patients undergoing open cholecystectomy (n = 16) or abdominal hysterectomy (n = 1) were studied. Anaesthesia with 65% xenon in oxygen was induced by ventilating the lungs through a circle system with minimal fresh gas flow. The echocardiographically obtained mean (SD) fractional area change in a short axis view of the left ventricle at the level of the papillary muscles was 65 (10)% (n = 14) before xenon. There was no significant change after 5, 10 and 15 min of xenon anaesthesia. Cerebral blood flow velocities were unchanged during the first 5 min of xenon anaesthesia, but were significantly increased in the left and right middle, and the right anterior, cerebral arteries after 15 and 30 min (n = 16) (p < 0.05). In conclusion, xenon anaesthesia had no adverse effect on myocardial function, but probably increased cerebral flood flow.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anesthesia, Inhalation*
  • Blood Flow Velocity / drug effects
  • Blood Pressure / drug effects
  • Cerebrovascular Circulation / drug effects*
  • Echocardiography, Transesophageal
  • Female
  • Heart Rate / drug effects
  • Humans
  • Male
  • Middle Aged
  • Time Factors
  • Ultrasonography, Doppler, Transcranial
  • Ventricular Function, Left / drug effects*
  • Xenon / pharmacology*

Substances

  • Xenon