Nat Genet. 1993 Nov;5(3):279-82.

Genetic mapping of a second locus predisposing to hereditary non-polyposis colon cancer.

Lindblom A, Tannergård P, Werelius B, Nordenskjöld M.

Source

Department of Clinical Genetics, Karolinska Hospital, Stockholm, Sweden.

Abstract

Hereditary colon cancer is caused by mutations in several different loci. The APC gene on chromosome 5 causing adenomatous polyposis coli represents a minority of the inherited colon cancer cases, while hereditary-non polyposis colon cancer (HNPCC) may cause five percent of all human colon cancer. One gene causing HNPCC was recently mapped to chromosome 2 but the same study also showed that at least one additional locus may cause HNPCC. We now present tight linkage between a polymorphic marker on the short arm of chromosome 3 and the disease locus, and find that these families also manifest signs of a general DNA replication disorder.

PMID:: 7903889; [PubMed - indexed for MEDLINE]

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Research Support, Non-U.S. Gov't

MeSH Terms

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DNA, Satellite

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