Lancet. 1978 Jul 29;2(8083):223-6.

Increased dopamine-receptor sensitivity in schizophrenia.

Owen F, Cross AJ, Crow TJ, Longden A, Poulter M, Riley GJ.

Abstract

Dopaminergic mechanisms have been investigated in post-mortem brain specimens from nineteen patients with schizophrenia and nineteen controls. Dopamine turnover was not increased in schizophrenic patients but, as assessed by the spiroperidol-binding technique, there was a significant increase in postsynaptic receptor sensitivity. The change in the dopamine receptor occurred in nucleus accumbens, putamen, and caudate nucleus. Increased dopamine-receptor sensitivity was present in five patients who had been free of neuroleptic medication for at least 1 year before death, and therefore may be related to the disease process.

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