Send to:

Choose Destination
See comment in PubMed Commons below
Nihon Rinsho. 1995 Jan;53(1):239-49.

[Structure and function of RAD51 gene in eukaryote].

[Article in Japanese]

Author information

  • 1Department of Biology, Osaka University, Faculty of Science.


RAD51 gene of S. cerevisiae is involved in DNA repair of double-strand breaks, mitotic and meiotic recombination. Rad51 protein is structurally similar to bacterial RecA proteins, which play crucial roles in recombination and DNA repair. Like RecA, Rad51 protein forms nucleofilament with a right handed helical structure, in which the DNA is extended 1.5 times than B-form DNA. Structural homologs have been cloned from various organisms including human and mouse. These results suggest that Rad51 is an essential recombination protein conserved from yeasts to human. Different from RecA, Rad51 protein requires at least an another protein, Rad52, to carry out recombination through the interaction between them.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk