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Genomics. 1994 Nov 1;24(1):27-33.

A novel cyclin gene (CCNF) in the region of the polycystic kidney disease gene (PKD1).

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  • 1Imperial Cancer Research Fund, London, United Kingdom.


The major locus for autosomal dominant polycystic kidney disease (PKD1) is located in a gene-rich region on chromosome 16p13.3. Recently the identification of the gene responsible for PKD1 has been described. While searching for candidate genes in this region, we isolated a new member of the cyclin family. We have characterized the transcript by sequencing, determination of the exon intron boundaries, and Northern blot analysis. Cyclin F is related to A- and B-type cyclins by sequence, but its function is unknown.

[PubMed - indexed for MEDLINE]
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