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Radiology. 1995 Apr;195(1):17-22.

Nephrotoxicity from contrast media: attenuation with theophylline.

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  • 1Prairie Education Research Cooperative, Springfield, Ill.

Abstract

PURPOSE:

To determine if depression of creatinine clearance after administration of contrast medium may be prevented with theophylline.

MATERIALS AND METHODS:

A nonionic, low-osmolality contrast medium (iopamidol) or an ionic, high-osmolality contrast medium (sodium diatrizoate) was administered to 93 patients. Before the examination, these patients were given theophylline or a placebo orally. There were also 30 patients who received an adenosine-uptake inhibitor (dipyridamole). Creatinine clearance and urinary adenosine levels were measured before and after angiography.

RESULTS:

Creatinine clearance decreased 18% +/- 4 in the placebo-iopamidol group but did not decrease in the theophylline group; urinary adenosine increased 67% +/- 7. Creatinine clearance decreased 42% +/- 5 in the placebo-sodium diatrizoate group and decreased 24% +/- 3 in the theophylline group; urinary adenosine increased 119% +/- 8. In the dipyridamole group in which iopamidol was given, urinary adenosine increased 96% +/- 7 and creatinine clearance decreased 37% +/- 5.

CONCLUSION:

Intrarenal adenosine can be implicated in the pathogenesis of hypertonic contrast medium nephrotoxicity.

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PMID:
7892462
[PubMed - indexed for MEDLINE]
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