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J Am Vet Med Assoc. 1994 Oct 15;205(8):1183-5.

Topical use of 5-fluorouracil for treatment of squamous cell carcinoma of the external genitalia of horses: 11 cases (1988-1992).

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  • 1Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.


Ten horses with histologically confirmed squamous cell carcinoma (SCC) and 1 horse with presumptive SCC of the external genitalia were treated with a combination of surgical debridement and topical administration of 5-fluorouracil, or with topical treatment alone. Tumor remission was obtained in all horses except 1 in which owner compliance was deficient, and no recurrences have been reported. Topical use of 5-fluorouracil as a chemotherapeutic agent for treatment of genital lesions of SCC in horses should be considered as a viable alternative to radical surgical excision.

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