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1: FEBS Lett. 1995 Mar 13;361(1):13-6.Click here to read Links

Molecular cloning and functional expression of a novel potassium channel beta-subunit from human atrium.

Majumder K, De Biasi M, Wang Z, Wible BA.

Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030.

We report the cloning and functional expression of a novel K+ channel beta-subunit from human atrium, hKv beta 3. hKv beta 3 is highly homologous to the two beta-subunits cloned from rat brain, Kv beta 1 and Kv beta 2, but has an essentially unique stretch of 79 N-terminal residues. Upon expression in Xenopus oocytes, hKv beta 3 accelerates the inactivation of co-injected hKv1.4 currents and induces fast inactivation of non-inactivating co-injected hKv1.5 currents. By contrast, hKv beta 3 had no effect on hKv1.1, hKv1.2, or hKv2.1 currents. Thus, hKv beta 3 represents a third type of K+ channel beta-subunit which modulates the kinetics of a unique subset of channels in the Kv1 subfamily.

PMID: 7890032 [PubMed - indexed for MEDLINE]

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