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Cancer Genet Cytogenet. 1995 Feb;79(2):104-10.

Deletion 6q in three cases of mixed-type liposarcoma in addition to t(12;16)(q13;p11)

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  • 1Cancer Center of Southwest Biomedical Research Institute, Scottsdale, Arizona 85251.

Erratum in

  • Cancer Genet Cytogenet 1995 May;81(1):101.


We report the cytogenetic findings in three mixed liposarcoma following short-term cultures. During the course of cytogenetic investigation of various types of liposarcomas, we observed an interstitial deletion of the long arm of chromosome 6 together with the translocation (12;16)(q13;p11) in three tumors. Translocation (12;16) is associated with myxoid and mixed (myxoid/round cell) liposarcomas, although deletion of chromosome 6 has been observed in only a few of these tumors. Our findings suggest that del(6), as an additional change in myxoid liposarcoma, is probably related to tumor progression.

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