phyllopod functions in the fate determination of a subset of photoreceptors in Drosophila

H C Chang; N M Solomon; D A Wassarman; F D Karim; M Therrien; G M Rubin; T Wolff

doi:10.1016/0092-8674(95)90497-2

phyllopod functions in the fate determination of a subset of photoreceptors in Drosophila

Cell. 1995 Feb 10;80(3):463-72. doi: 10.1016/0092-8674(95)90497-2.

Authors

H C Chang¹, N M Solomon, D A Wassarman, F D Karim, M Therrien, G M Rubin, T Wolff

Affiliation

¹ Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley 94720-3200.

PMID: 7888014
DOI: 10.1016/0092-8674(95)90497-2

Abstract

phyllopod (phyl) encodes a novel protein required for fate determination of photoreceptors R1, R6, and R7, the last three photoreceptors to be recruited into the ommatidia of the developing Drosophila eye. Genetic data suggests that phyl acts downstream of Ras1, raf, and yan to promote neuronal differentiation in this subset of photoreceptors. Ectopic expression of phyl in the cone cell precursors mimics the effect of ectopic activation of Ras1, suggesting that phyl expression is regulated by Ras1. phyl is also required for embryonic nervous system and sensory bristle development.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Amino Acid Sequence
Animals
Base Sequence
Cell Differentiation
Cloning, Molecular
Drosophila / embryology
Drosophila / genetics*
Drosophila Proteins*
Eye / growth & development
Gene Expression Regulation, Developmental*
Genes, Insect / genetics
Larva
Molecular Sequence Data
Nervous System / embryology
Nuclear Proteins / genetics*
Nuclear Proteins / physiology
Photoreceptor Cells, Invertebrate / cytology*
Sequence Analysis, DNA
Suppression, Genetic
ras Proteins / physiology

Substances

Drosophila Proteins
Nuclear Proteins
phyl protein, Drosophila
ras Proteins

Associated data

GENBANK/U19722
GENBANK/U19731