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Nature. 1995 Mar 23;374(6520):327-37.

Structural basis of cell-cell adhesion by cadherins.

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  • 1Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032.

Abstract

Crystal structures of the amino-terminal domain of N-cadherin provide a picture at the atomic level of a specific adhesive contact between cells. A repeated set of dimer interfaces is common to the structure in three lattices. These interactions combine to form a linear zipper of molecules that mirrors the linear structure of the intracellular filaments with which cadherins associate. This cell-adhesion zipper may provide a mechanism to marshal individual molecular adhesive interactions into strong bonds between cells.

PMID:
7885471
[PubMed - indexed for MEDLINE]
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