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Immunol Today. 1995 Jan;16(1):34-8.

Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases.

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  • 1Dept of Microbiology and Immunology, Stanford University School of Medicine, CA 94305-5402.


CD4+ T cells play a key role in regulating immune system function. When these regulatory processes go awry, organ-specific autoimmune diseases may develop. Here, Roland Liblau, Steven Singer and Hugh McDevitt explore the thesis that a particular subset of CD4+ T cells, namely T helper 1 (Th1) cells, contributes to the pathogenesis of organ-specific autoimmune diseases, while another subset, Th2 cells, prevents them.

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