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Science. 1995 Mar 10;267(5203):1485-8.

Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation.

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  • 1National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1876.


I kappa B-alpha inhibits transcription factor NF-kappa B by retaining it in the cytoplasm. Various stimuli, typically those associated with stress or pathogens, rapidly inactivate I kappa B-alpha. This liberates NF-kappa B to translocate to the nucleus and initiate transcription of genes important for the defense of the organism. Activation of NF-kappa B correlates with phosphorylation of I kappa B-alpha and requires the proteolysis of this inhibitor. When either serine-32 or serine-36 of I kappa B-alpha was mutated, the protein did not undergo signal-induced phosphorylation or degradation, and NF-kappa B could not be activated. These results suggest that phosphorylation at one or both of these residues is critical for activation of NF-kappa B.

[PubMed - indexed for MEDLINE]
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