Nature. 1995 Mar 9;374(6518):131-4.

Principles of CDK regulation.

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Department of Physiology, University of California, San Francisco 94143-0444.

Abstract

As key regulators of the cell cycle, the cyclin-dependent kinases must be tightly regulated by extra- and intracellular signals. The activity of cyclin-dependent kinases is controlled by four highly conserved biochemical mechanisms, forming a web of regulatory pathways unmatched in its elegance and intricacy.

PMID:: 7877684; [PubMed - indexed for MEDLINE]

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