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Gastroenterol Clin Biol. 1994;18(10):813-8.

[Prevalence and significance of non-specific anti-organelle antibodies of the liver in chronic viral hepatitis C].

[Article in French]

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  • 1Service d'Hépato-Gastroentérologie, Groupe Hospitalier Pitié-Sqalpêtrière, Paris.

Abstract

OBJECTIVES:

The aim of this study was to evaluate the prevalence and the clinical signification of non organ specific autoantibodies in chronic hepatitis C.

METHODS:

We studied retrospectively 158 consecutive patients (97 with chronic hepatitis C, 24 with chronic hepatitis B, 67 with alcoholic cirrhosis) and 100 blood-donors.

RESULTS:

The prevalence of anti-nuclear and anti-smooth muscle antibodies was lower in blood donors than in patients (P < 0.001), but was comparable among the 3 groups of patients. The anti-liver-kidney microsome type 1 antibodies were detected only in patients with chronic hepatitis C (6%). The serum gammaglobulin level was significantly higher in patients with hepatitis C and anti-nuclear antibody titers > or = 1/50. The anti-smooth muscle antibodies detected in patients with hepatitis C had no anti-actin specificity. The response to interferon was not related to the detection of non organ specific autoantibodies before treatment.

CONCLUSION:

Anti-nuclear or anti-smooth muscle antibodies are not characteristic of hepatitis C virus infection.

PMID:
7875387
[PubMed - indexed for MEDLINE]
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